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The success of oral semaglutide and the wider oral GLP-1 pipeline shows that more complex therapies can move into solid oral dosage forms

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However, surgery is unlikely to be a feasible population-level solution, due to the nature of complications, limited healthcare capacity and acceptability

and number of participants who experienced each outcome or SAEs

Interestingly, when both receptors are stimulated togetheras with Tirzthe result may be greater than the sum of its parts, offering improved glucose control and appetite regulation in animal models compared to GLP-1 agonism alone